A recent study looked at the health claims and safety of ashwagandha and found that the herb has shown anticancer, anti-inflammatory, heart-protective, liver-protective, and immunomodulatory (able to change the immune system) actions. 1992;30(3):169-172. Sleep Sci. As this is a relatively new area of research, more vigorous studies are needed. J Ethnopharmacol. Taking ashwagandha with thyroid hormone pills might cause too much thyroid hormone in the body, and increase the effects and side effects of thyroid hormone. Cookies collect information about your preferences and your devices and are used to make the site work as you expect it to, to understand how you interact with the site, and to show advertisements that are targeted to your interests. drugs for diabetes and blood pressure). It is also recommended that people with hormone-sensitive prostate cancer avoid using ashwagandha due to possible hormone changes caused by the herb. There is no scientific evidence to support one supplement form over another, which means you should choose the one that best fits your lifestyle. 2011;68(1):3-8. Sharada, A. C., Solomon, F. E., Devi, P. U., Udupa, N., and Srinivasan, K. K. Antitumor and radiosensitizing effects of withaferin A on mouse Ehrlich ascites carcinoma in vivo. 2021;270:113766. 2020;12(2):e7083. Anyone with upcoming surgery should stop using ashwagandha at least two weeks prior. Biswal BM, Sulaiman SA, Ismail HC, Zakaria H, Musa KI. View abstract. Indian J Physiol Pharmacol. Many of the studies on ashwagandha have been performed in laboratory settings or on animal models, but some human trials do exist. View abstract. However, the review noted various limitations of the studies, including study design and potential bias. Int.J.Crude Drug Res. Neurol India 2009;57:166-71. Expert Rev Clin Pharmacol. 2013;12(4):312-22. doi:10.1371/journal.pone.0257843, Verma N, Gupta SK, Tiwari S, Mishra AK. J Res Ayur Sid 1980;1:370-385. Pusec CM, Wolsky R, Llerena C, Sura P. A Case of Supplement-Induced Hepatitis. Ashwagandha is popular in Ayurveda medicine, and Indians have used it for more than 3,000 years to treat a wide range of healthy disorders. Are there any side effects of ashwagandha? View abstract. Ireland PJ, Hardy T, Burt AD, Donnelly MC. Brittany Lubeck, RD, is a nutrition writer and registered dietitian with a master's degree in clinical nutrition. Therefore, it is recommended to consult with a healthcare professional before adding ashwagandha to a weight loss plan, especially if you have any underlying medical conditions or are taking any medications . lisinopril, captopril, benazepril, quinapril), ARBs (e.g. Ashwagandha has mild interactions with at least 29 different drugs. However, these results have not been proven in humans. Journal of Research in Ayurveda and Siddha 1980;1(2):247-258. Liver Int. It is not meant to be comprehensive and should be used as a tool to help the user understand and/or assess potential diagnostic and treatment options. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Always talk with a healthcare provider before starting any new supplement regimen. Ultimately, the supplements and foods you can . Ashwagandha can increase the activity of the immune system. Twelve studies were included in the final review, and researchers concluded that ashwagandha showed more improvements in physical performance than placebo pills. Cureus 2022;14(10):e30787. Drug-induced hepatocellular injury due to herbal supplement ashwagandha. Ashwagandha. While the side effects of ashwagandha are minimal, some people may experience: Gastrointestinal upset. A variety of of vitamins and nutritional supplements have been shown to help treat depression. People with thyroid conditions or who are taking thyroid medications should talk with a healthcare provider before using ashwagandha. Mishra LC, Singh BB, Dagenais S. Scientific basis for the therapeutic use of Withania somnifera (ashwagandha): a review. Does Ambien Cause Withdrawal Symptoms After Stopping? View abstract. View abstract. Yakugaku Zasshi 2008;128(8):1159-1167. This means they can cause drug-drug interactions, and they can have all the usual side effects and risks that pharmaceutical can have. View abstract. This information does not contain all possible interactions or adverse effects. These medications work in the brain by indirectly enhancing the action of a chemical in the brain called gamma-aminobutyric acid (GABA) a neurotransmitter that has a calming effect which helps lower anxiety levels. Ashwagandha has not been well studied in regard to potential interactions with prescription medication. Deshpande A, Irani N, Balkrishnan R, Benny IR. 2012;34(3):255-62. Anbalagan K and Sadique J. Withania somnifera (ashwagandha), a rejuvenating herbal drug which controls alpha-2 macroglobulin synthesis during inflammation. Ashwagandha may be toxic to the liver (hepatotoxic). J Ethnopharmacol 1998;62:209-14. Safety studies have not been performed on these populations, so it's best to avoid using ashwagandha altogether while pregnant or breastfeeding. Phytotherapy Research 1989;3(5):201-206. Nonetheless, additional large-scale, long-term studies would strengthen these findings. It is commonly used for stress. Nat.Prod.Res 2005;19(6):567-571. According to their lab study, withanone may interfere with DNA, leading to liver damage. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. View abstract. This information does not endorse any treatments or medications as safe, effective, or approved for treating a . Ashwagandha is purported as useful for relieving stress, fatigue, pain and gastrointestinal problems, and treating diabetes, rheumatoid arthritis and epilepsy. 2022;15(9):1067-1080. doi:10.1080/17512433.2022.2121699, Salve J, Pate S, Debnath K, Langade D. Adaptogenic and anxiolytic effects of Ashwagandha root extract in healthy adults: a double-blind, randomized, placebo-controlled clinical study. For example, it may increase the sedative effect of medications that treat anxiety and insomnia. Aerobic capacity and recovery were assessed for all participants throughout the study. The combination could decrease the effectiveness of these medications. You will need to talk about the benefits and risks of using this natural product. Kulkarni, S. K. and Dhir, A. Withania somnifera: an Indian ginseng. Can You Take A Z-Pak If You Have A Penicillin Allergy? Panda S, Kar A. Withania somnifera and Bauhinia purpurea in the regulation of circulating thyroid hormone concentrations in female mice. Safety and adverse events were also not well-reported in the studies used in the review. WebMD does not provide medical advice, diagnosis or treatment. Ahumada F, Aspee F, Wikman G, and et al. Pharmacol Biochem.Behav 2003;75(3):547-555. Evaluation of the efficacy of withania somnifera (ashwagandha) root extract in patients with obsessive-compulsive disorder: a randomized double-blind placebo-controlled trial. A study compared ashwagandha to a placebo to determine whether the herb would have a positive effect on insomnia. PLoS One. Kelgane SB, Salve J, Sampara P, Debnath K. Efficacy and tolerability of ashwagandha root extract in the elderly for improvement of general well-being and sleep: A prospective, randomized, double-blind, placebo-controlled study. 2021 Feb 11;6(1):20. doi: 10.3390/jfmk6010020. View abstract. The most common side effects include: Other less common side effects of ashwagandha include: If you experience side effects when taking ashwagandha, be sure to stop using it and seek advice from a healthcare provider. It may also interact with other herbs, supplements, and even foods. Dietary supplements are not regulated like drugs in the United States, meaning the Food and Drug Administration (FDA) does not approve them for safety and effectiveness before products are marketed. However, even if supplements are third-party tested, they are necessarily safe for all or effective in general. Dr. Brian has been practicing pharmacy for over 13 years and has wide-ranging experiences in many different areas of the profession. View abstract. Bonilla DA, Moreno Y, Gho C, Petro JL, Odriozola-Martnez A, Kreider RB. In fact, according to the book Depression in Adults With a Chronic Physical Health Problem: Treatment and Management, published in 2010 by the British Psychological Society, there are no specific vitamins contraindicated for consumption with antidepressants. View abstract. For more information on drug interactions, visit the RxList Drug Interaction Checker. Gopal S, Ajgaonkar A, Kanchi P, et al. According to the Mayo Clinic, all of these SSRIs work by blocking the reuptake of serotonin in the brain, which essentially makes serotonin more available. Essential vitamins, minerals and amino acids that are involved in neurobiological function include: However, several of these have had mixed results in helping support depression treatment. Agnihotri AP, Sontakke SD, Thawani VR, Saoji A, Goswami VS. Monitor your blood sugar closely. Kamal HI, Patel K, Brdak A, Heffernan J, Ahmad N. Ashwagandha as a unique cause of thyrotoxicosis presenting with supraventricular tachycardia. View abstract. View abstract. Another study (a systematic review and meta-analysis) found that ashwagandha may benefit athletes. Thank you, {{form.email}}, for signing up. Clinical Evaluation of the Spermatogenic Activity of the Root Extract of Ashwagandha (Withania somnifera) in Oligospermic Males: A Pilot Study. View abstract. Last updated on Feb 3, 2023. View abstract. When taken inappropriately, ashwagandha can have side effects and potentially serious medicinal interactions. View abstract. View abstract. When possible, choose a supplement tested by a trusted third party, such as U.S. Pharmacopeia (USP), ConsumerLab, or NSF. Upadhaya L and et al. Talk with a healthcare provider about the right ashwagandha dosage for your needs. These are drugs like diazepam, lorazepam, phenobarbital, or zolpidem. If possible, choose an ashwagandha supplement that has been reviewed and approved by a third-party agency, like USP, NSF International, or ConsumerLab. It is commonly used for stress. These supplements may contain similar active ingredients or have potential uses that are like those of ashwagandha. Within this specific study, participants were randomized to receive a placebo (sugar pill with no active ingredients), an ashwagandha dose of 250 milligrams (mg) per day or 600 milligrams per day. Data sources include IBM Watson Micromedex (updated 2 Apr 2023), Cerner Multum (updated 17 Apr 2023), ASHP (updated 10 Apr 2023) and others. Deocaris, C. C., Widodo, N., Wadhwa, R., and Kaul, S. C. Merger of ayurveda and tissue culture-based functional genomics: inspirations from systems biology. Health Sci Rep 2022;5(4):e741. The roots can be used topically as a poult. 8 Warning Signs of Depression You Shouldn't Ignore, Depression in Adults With a Chronic Physical Health Problem: Treatment and Management, How Vegans Can Get All Their Nutrients (Without Taking Supplements), Complementary Therapies in Medicine Journal, 15 Celebrities Who Struggle With Anxiety and Depression, Australian Journal of Herbal Medicine: "B Vitamins Enhance Antidepressant Response in Adults", Open Neurology Journal: "Vitamin B12 Supplementation in Treating Major Depressive Disorder: A Randomized Controlled Trial", Journal of Psychiatry: "Adjunctive Nutraceuticals for Depression: A Systematic Review and Meta-Analyses", Mayo Clinic: "MAOIs and Diet: Is It Necessary to Restrict Tyramine? J Clin Lab Anal 2008;22:295-301. Chitre D, Nadkarni S, Jagtap N, et al. Ashwagandha May Interact With Certain Drugs. J Ethnopharmacol. These side effects are usually experienced on higher doses. Agarwal R, Diwanay S, Patki P, Patwardhan B. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version. J Ethnopharmacol. Ashwagandha has mild interactions with at least 29 different drugs. A double-blind, randomized, placebo-controlled trial on the effect of Ashwagandha (Withania somnifera dunal.) Dhuley, J. N. Effect of ashwagandha on lipid peroxidation in stress-induced animals. Some of these interactions can be life-threatening. The specific components of physical performance included strength and power, endurance, and fatigue/recovery. Take ashwagandha with these drugs only under your doctor's supervision, recommends the Langone Medical Center at New York University. Phytother Res 2022. Copyright 2023 UpToDate, Inc. and its affiliates and/or licensors. Effects of L-Theanine administration on stress-related symptoms and cognitive functions in healthy adults: a randomized controlled trial. View abstract. Ashwaganda is used to treat Herbal Supplementation. Next Steps to Take, Understanding Your Childs Life With ADHD. 2021;18(2):183-226. doi:10.1080/19390211.2020.1741484, D'Cruz M, Andrade C. Potential clinical applications of Ashwagandha (Withania somnifera) in medicine and neuropsychiatry. According to a December 2012 study in the Journal of Medicine and Life, SSRIs are primarily the recommended treatment for depression. National Center for Complementary and Integrative Health. Therefore, before using this product, tell your doctor or pharmacist of all the . Ashwagandha might lower blood pressure. However, some adverse effects are generally associated with ashwagandha. Evid Based Complement Alternat Med. Cureus. Effect of Asian ginseng, Siberian ginseng, and Indian ayurvedic medicine Ashwagandha on serum digoxin measurement by Digoxin III, a new digoxin immunoassay. A randomized double blind placebo controlled study of ashwagandha on generalized anxiety disorder. Take extra care driving and doing tasks that you need to be alert for while taking this product. Nevertheless, be sure to talk to your doctor before adding on ashwagandha to blood pressure medicine, such as: Ashwagandha might increase the effects and adverse effects of thyroid hormone drugs. Often, herbs and supplements come with a risk of side effects. . Who Shouldn't Take Ashwagandha? Feel free to send him an email at Hello@HelloPharmacist.com! Akhgarjand C, Asoudeh F, Bagheri A, et al. Indian J Exp Biol. Begum, V. H. and Sadique, J. Hence, be cautious if taking these medications and want to take Ashwagandha also. Per the review, five people experienced liver toxicity after taking varying brands and doses of ashwagandha for different lengths of time. Am J Ther 2023;30(1):e80-e83. Some but not all ashwagandha supplements are organic. Guerrero FA, Medina GM. View abstract. J Evid Based Complementary Altern Med. In comparison, a small human trial published in 2022 showed additional proof that ashwagandha may be helpful for people living with anxiety. Singh P, Salman KA, Shameem M, Warsi MS. Withania somnifera (L.) Dunal as add-on therapy for COPD patients: a randomized, placebo-controlled, double-blind study. You can also connect with Dr. Brian Staiger on LinkedIn. No supplement is intended to treat, cure, or prevent disease. Additionally, ashwagandha may increase testosterone levels in the body. Ashwagandha may increase thyroid hormone levels. 2021 Nov 25;13(2):100510. Due to an overall lack of scientific evidence, there are no standard dosage guidelines for ashwagandha. Investigation of CYP2B6, 3A4 and -esterase interactions of Withania somnifera (L.) dunal in human liver microsomes and HepG2 cells. Bjrnsson HK, Bjrnsson ES, Avula B, et al. If you are experiencing serious medical symptoms, please see the An eight-week safety study found that taking 300 milligrams daily of ashwagandha was safe for both males and females. Nutrients. 2021;16(9):e0257843. We have said that the elements ashwagandha meds of will ashwagandha interact with diabetic meds cause, ashwagandha interact diabetic principle and ontology are the objects of our research. J.Transl.Med. Ashwagandha side effects. Additionally, a pilot study looked at ashwagandha's effects on people with mild cognitive impairment. 2005 - 2023 WebMD LLC, an Internet Brands company. Although side effects do not always occur, you may experience drowsiness, stomach pain, or loose stools when taking ashwagandha. View abstract. The liver damage never progressed to liver failure, and most cases were resolved within five months. This product can contain high amounts of iron. Skinmed. Does Synthroid interact with supplements that may help with arthritis, such as ashwagandha, collagen, or turmeric? Immunomodulatory and CNS effects of sitoindosides 9 and 10, two new glycowithanolides from Withania somnifera. Xanax is in the drug class benzodiazepines. According to an April 2016 review in the Journal of Psychiatry, several nutrients are involved in healthy brain activity. However, some other statins do not seem to be affected by grapefruit juice, including pravastatin (Pravachol), fluvastatin (Lescol) and rosuvastatin (Crestor). Int Ayurvedic Med J 2013;1(5):1-7. Read More. Ultimately, the supplements and foods you can safely ingest depend entirely on the antidepressant. Learn about the uses and potential benefits of Ashwagandha including dosage guidelines, side effects, interactions and safety/efficacy ratings. Does Ashwagandha Interact With Any Medications? Sriranjini SJ, Pal PK, Devidas KV, Ganpathy S. Improvement of balance in progressive degenerative cerebellar ataxias after Ayurvedic therapy: a preliminary report. Lousewort - Amiloride, Hydrochlorothiazide, Cassia Cinnamon - Aspirin, Butalbital, Caffeine, Abuta - Bismuth Subcarbonate, Calcium Carbonate, Opium, English Adder's Tongue - Inotuzumab Ozogamicin, Patricia Kane (pk) Protocol - Indomethacin, Pulsed Electromagnetic Field (pemf) Therapy - Cabozantinib. Curr Clin Pharmacol. Use WebMD's Drug Interaction Checker tool to find and identify potentially harmful and unsafe combinations of prescription medications by entering two or more drugs in question. 2019;11(12):e6466. There are a variety of essential vitamins and minerals you should consume on a daily basis. Katz M, Levine AA, Kol-Degani H, Kav-Venaki L. A compound herbal preparation (CHP) in the treatment of children with ADHD: a randomized controlled trial. Liver damage. Most ashwagandha supplements are naturally vegan and gluten-free. PLoS.One. Its scientific name is Withania somnifera Dunal, and it belongs to a class of herbs called rasayana, praised for their revitalizing effects on health.