2020;34(6):1446-1454. doi:10.1002/ptr.6620. If you have diabetes, use milk thistle with caution, since the supplement might lower blood sugar. Quality and active ingredients in supplements may vary widely from maker to maker. Silymarin in Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Effect of silymarin (milk thistle) on liver disease in patients with chronic hepatitis C unsuccessfully treated with interferon therapy: a randomized controlled trial. J Med Assoc Thai. Milk thistle. Interestingly, one study found that people with acne who took 210 milligrams of silymarin per day for 8 weeks experienced a 53% decrease in acne lesions (42). Mayo Clinic does not endorse companies or products. Milk thistle can trigger allergic reactions. Effects of vitamin E on chronic hepatitis C genotype 3: a randomized, double-blind, placebo-controlled study. One particular area of interest is in milk thistle's ability to protect and perhaps restore the liver. Please enable it to take advantage of the complete set of features! Silibinin, a flavonoid derived from milk thistle (Silybum marianum), has been used as a hepato-protectant in the clinical treatment of liver diseases. There are no other food sources of this herb. The flavonoid complex silymarin in preclinical studies has been found to increase serotonin and dopamine levels in the cortex. Milk thistle is thought to be safe for most people, but precautions should be taken as side effects are possible. Acne is a chronic inflammatory skin condition. Questions? Other uses not proven with research have included treating malaria, mushroom poisoning, spleen or gallbladder problems, menstrual problems, liver problems (such as hepatitis B or C), and other conditions. other information we have about you. Neurological Disorders Milk thistle has long been used to alleviate the inflammation commonly associated with a host of neurological disorders such as dementia, Alzheimers, and Parkinsons Disease (8). This is especially important if you are taking any other medications for menopause or any blood thinners, such as statins. Some people may be allergic to milk thistle. the unsubscribe link in the e-mail. Depression is one of the most frequent psychiatric disorders of Alzheimer's disease (AD). Together, you can make shared, well-informed decisions. Fried, M.; Navarro, V.; Afdhal, N. et al. Talk with your healthcare provider before starting milk thistle to make sure it is the right supplement for you. Read our. Cochrane Database Syst Rev. https://www.wolterskluwercdi.com/facts-comparisons-online/. Dupuis ML, Conti F, Maselli A, et al. In test-tube and animal studies, silymarin has been shown to prevent oxidative damage to brain cells, which could help prevent mental decline (16, 17). People have traditionally used milk thistle for problems with the liver and gallbladder . Abdulghani A, Poghosyan M, Mehren A, Philipsen A, Anderzhanova E. Front Mol Neurosci. Milk thistle is sold as an oral capsule, tablet and liquid extract. In one clinical trial, 60 people with benign polyps in the colon (which often develop into colon cancer) took a herbal blend with milk thistle, a flaxseed antioxidant, and oat fiber for 2 . Clin Exp Pharmacol Physiol. 2017 Apr;42(4):1073-1083. doi: 10.1007/s11064-016-2141-4. Taken in appropriate doses, oral use of milk thistle appears to be safe. Anticancer Drugs. The therapeutic potential of milk thistle in diabetes. eCollection 2023. Milk thistle has been used as a traditional remedy for neurological conditions like Alzheimers and Parkinsons disease for over two thousand years (13). Its regularly used as a complementary therapy by people who have liver damage due to conditions like alcoholic liver disease, non-alcoholic fatty liver disease, hepatitis and even liver cancer (1, 5, 6). Its been suggested that oxidative stress in the body may play a role in the development of acne (41). Side effects. Disclaimer. Milk thistle has been used to treat disorders of the liver and gallbladder for at least 2,000 years. Rambaldi, A.; Jacobs, B.; Iaquinto G, Gluud C. Milk thistle for alcoholic and/or hepatitis B or C liver diseases--a systematic Cochrane hepato-biliary group review with meta-analyses of randomized clinical trials. People who are allergic to artichokes, kiwi, ragweed, daisies, marigolds, and chrysanthemums are at higher risk. After using 2 tablets a day and 1 month, indigestion and pain in my liver disappeared. This publication is not copyrighted and is in the public domain. Era of Hope Meeting for the Department of Defense Breast Cancer Research Program, Atlanta, June 8-11, 2000. Silymarin is an active component of milk thistle, which is not found in foods. Moreover, silibinin was able to attenuate the neuronal damage in the hippocampus of A1-42-injected rats. Milk thistle has been used in alternative medicine as a possibly effective aid in treating heartburn, or seasonal allergy symptoms. Its herbal remedy is known as milk thistle extract. Below is a short list of 4 widely available and very affordable herbs with some serious natural health benefits for OCD sufferers: Before introducing milk thistle into your diet, new supplements or any other herbs for OCD for that matter you should consult your physician. The information and products shown on this website should not be interpreted as a substitute for physician evaluation or treatment. Memorial Sloan-Kettering Cancer Center: About Herbs: Milk thistle., Natural Standard Patient Monograph: Milk thistle.. By Brittany Lubeck, RD Sign up for free, and stay up to date on research advancements, health tips and current health topics, like COVID-19, plus expertise on managing health. Summary Milk thistle may increase breast milk production in women who are lactating, though very little research has been done to confirm its effects. Silymarin (milk thistle extract) as a therapeutic agent in gastrointestinal cancer. Adv Ther. 2011;17(18):2288-2301. doi:10.3748/wjg.v17.i18.2288. 2015;22(2):290-6. doi:10.1016/j.phymed.2014.12.010. Milk thistle might also help prevent insulin resistance and slow the growth of cancer,. When looking at Milk Thistle itself (prior to any extraction), the fruits or thistles contain: Silymarin at 1.5-3% of dry weight (to be elucidated later) [2] Silyhermin and both Neosilyhermin A and B [2]; Protein and Mucilage (taking up 25-30% of the herb by dry weight) [2] Quercetin and the dihydro varient known as Taxifolin [2]; Kaempferol, Dihydrokaempferol, and the 7-glucoside and 3 . Effect of silymarin on chemical, functional, and morphological alterations of the liver. Interactions. Well go over some of its most well-known benefits, Many people are interested in herbal supplements to support their liver health. Loguercio C, Festi D. Silybin and the liver: from basic research to clinical practice. 2023 Healthline Media LLC. Accessed Oct. 30, 2020. Experts believe silymarin is the primary active ingredient of the herb. Also notable is the fact that, of the 40 subjects that completed this trial, none had any adverse events or side effects with milk thistle supplementation (7). Summary Milk thistle may help lower blood sugar levels in people with type 2 diabetes, though more high-quality studies are needed. 1998-2023 Mayo Foundation for Medical Education and Research (MFMER). Matutino Santos P, Pereira Campos G, Nascimento C. Neuropsychiatr Dis Treat. In one such study, a 45-day course of silymarin, the active component of milk thistle, increased antioxidant capacity and reduced generalized inflammation in adults with type 2 diabetes compared with a placebo. Keep in mind that supplement use should be individualized and vetted by a healthcare professional, such as a registered dietitian, pharmacist, or healthcare provider. Mayo Clinic College of Medicine and Science, Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic School of Graduate Medical Education, Mayo Clinic School of Continuous Professional Development, Mayo Clinic on Incontinence - Mayo Clinic Press, NEW Mayo Clinic on High Blood Pressure - Mayo Clinic Press, Mayo Clinic on Hearing and Balance - Mayo Clinic Press, FREE Mayo Clinic Diet Assessment - Mayo Clinic Press, Mayo Clinic Health Letter - FREE book - Mayo Clinic Press, Financial Assistance Documents Minnesota, Gastrointestinal issues, such as diarrhea, constipation, nausea, vomiting and abdominal bloating. Fluoxetine is whats known as a selective serotonin reuptake inhibitor (SSRI) which aims to increase serotonin levels in the brain. Summary The active ingredients in milk thistle have been shown in animals to improve the effects of some cancer treatments. Silymarin, a milk thistle element, is reported safe at doses of 700 milligrams three times a day for 24 weeks. Milk thistle ( Silybum marianum) is an herbal remedy used mainly to protect and detoxify the liver. Biomed Res Int. 2020 Feb;47(2):302-312. doi: 10.1111/1440-1681.13201. However, the evidence is conflicting. All rights reserved. Mol Med Rep. 2016;13(4):3243-8. doi:10.3892/mmr.2016.4887, Yang Z, Zhuang L, Lu Y, Xu Q, Chen X. Milk thistle may be useful in treating liver disease, cancer, and diabetes. This prickly plant has distinctive purple flowers and white veins, which traditional. Natural Medicines Comprehensive Database: "Milk Thistle Monograph. Milk thistle may cause an allergic reaction in those with allergies to plants in the same family, like ragweed, chrysanthemum, marigold, and daisy. Brain Fog (anxiety, depression, ADHD), lots of medications. In: Textbook of Natural Medicine. Debra Rose Wilson, Ph.D., MSN, R.N., IBCLC, AHN-BC, CHT, The 10 Best Herbs for Liver Health: Benefits and Precautions, How to Get Rid of Acne: 14 Home Remedies for Pimples. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Liver Detoxification and Health. WebMD does not provide medical advice, diagnosis or treatment. PMC It is also unknown whether milk thistle is safe for children. (silymarin) extract supplementation on antioxidant status and hs-CRP in patients with type 2 diabetes mellitus: a randomized, triple-blind, placebo-controlled clinical trial, Silymarin in type 2 diabetes mellitus: a systematic review and meta-analysis of randomized controlled trials, Botanicals and their bioactive phytochemicals for women's health, Silymarin and hepatocellular carcinoma: a systematic, comprehensive, and critical review, Silymarin (milk thistle extract) as a therapeutic agent in gastrointestinal cancer. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. The review went on to say that silymarin may be linked to lower rates of mortality in patients with cirrhosis and liver disease. The benefits of milk thistle are believed to come from silymarin, an anti-inflammatory compound present throughout the entire plant, but highly concentrated in milk thistle seeds (4). However, the studies in humans are very limited and have yet to show a meaningful clinical effect in people (32, 33, 34, 35, 36). Epub 2016 Mar 9. Minerals for OCD In fact, in studies where high doses were used for long periods, only about 1% of people experienced side effects (1). Several studies have suggested that milk thistle may be beneficial for people with type 2 diabetes. Research on milk thistle use for specific conditions shows: Milk thistle might play a role in treating certain liver conditions. Its unclear what benefits, if any, it may have in the body, but its sometimes used as a natural treatment for things including cirrhosis, jaundice, hepatitis, and gallbladder disorders. https://www.micromedexsolutions.com. People mainly use the supplement to treat liver conditions. There is no standardized dosage or recommended intake for milk thistle tea, but it's generally considered safe if consumed in moderation. Not only does this help prevent cirrhoris, but may also be advantageous for those living with hepatitis or other liver diseases. Do not use more of this product than is recommended on the label. You should not use this product if you are allergic to milk thistle or if you have: past or present cancer of the breast, uterus, or ovary; or. Neuroplasticity to autophagy cross-talk in a therapeutic effect of physical exercises and irisin in ADHD. J Diabetes Res. Some supplements are close to chemicals in efficacy like saffron (standardized extract) for depression and magnolia bark extract for anxiety. Before Milk thistle is a popular herbal remedy best known for its liver-protecting properties. One human trial found it to work as well as fluoxetine to manage OCD symptoms. It is primarily considered a cleansing agent and used to block or flush toxins from the body. Can Milk Thistle Help People With Diabetes? See additional information. (silymarin) extract supplementation on antioxidant status and hs-CRP in patients with type 2 diabetes mellitus: a randomized, triple-blind, placebo-controlled clinical trial. Ask a doctor, pharmacist, or other healthcare provider if it is safe for you to use this product if you have: an allergy to plants such as ragweed, chrysanthemums, marigolds, or daisies. Some studies also show milk thistle may help people whose liver is damaged by industrial toxins, such as toluene and xylene. "It helps to clear out the toxins and nourish the organ," says Justice. One of the active ingredients in milk thistle called silymarin is extracted from the plant's seeds. More research is needed to confirm these results and the safety of milk thistle for breastfeeding mothers (38, 39, 40). However, there are currently no human studies examining the effects of milk thistle in people with Alzheimers or other neurological conditions like dementia and Parkinsons. Careers. Milk thistle is found throughout the eastern United States, California, South America, Africa, Australia, and Asia. Consult with a licensed healthcare professional before using any herbal/health supplement. But the herb is also believed to be beneficial for other health issues. A double-blind controlled study. Milk thistle is sometimes used to treat skin conditions including mild psoriasis. Common side effects of milk thistle reported in studies include: Typically, side effects will subside once you stop using milk thistle. Rev Diabet Stud. This article reviews what milk thistle is and, Milk thistle tea is said to protect the liver, stimulate breast milk production, and lower blood sugar levels. Small Business Research Grant Program (SBIR), About Research Training and Career Development, Training Grant Application, Review, and Award Process, Integrative Medicine Research Lecture Series, Division of Extramural Research Sponsored by NCCIH, Division of Intramural Research Conducted at NCCIH, Know the Science: How Medications and Supplements Can Interact, Know the Science: How To Make Sense of a Scientific Journal Article, How To Find Information About Complementary Health Approaches on PubMed, Dietary Supplements: What You Need To Know. https://www.nccih.nih.gov/health/milk-thistle. This may be because people arent able to absorb enough to get a medicinal effect. Its also used to protect the liver against toxins like amatoxin, which is produced by the death cap mushroom and is deadly if ingested (7, 8). Unable to load your collection due to an error, Unable to load your delegates due to an error. JIN_FK8R Please rate my stack I know I'm Fxxked up for now. edeka3 Brain Fog (anxiety, depression, ADHD), lots of medications. 2016;5147468. doi:10.1155/2016/5147468. Song X, Zhou B, Cui L, Lei D, Zhang P, Yao G, Xia M, Hayashi T, Hattori S, Ushiki-Kaku Y, Tashiro SI, Onodera S, Ikejima T. Neurochem Res. Medicinal use of this product has not been approved by the FDA. 2021;142:112024. doi:10.1016/j.biopha.2021, Walsh JA, Jones H, Mallbris L, et al. From aloe to honey, you might be surprised what basic ingredients can help improve breakouts. Do not use different forms (tablets, liquid, extract, teas, etc) of milk thistle at the same time without medical advice. Milk thistle can cause: Gastrointestinal issues, such as diarrhea, constipation, nausea, vomiting and abdominal bloating Itchiness Headache If you have diabetes, use milk thistle with caution, since the supplement might lower blood sugar. and transmitted securely. Federal government websites often end in .gov or .mil. The benefits of milk thistle remain unclear for this purpose and the limited research on milk thistle and breast milk has been done primarily in animals. Therefore, it is not known whether milk thistle or silymarin should be used to treat cirrhosis. Milk thistle (Silybum marianum) is a flowering plant belonging to the Asteraceae (daisy) family. Drug class: Herbal products. It may also make chemotherapy work more effectively against certain cancers and, in some circumstances, even destroy cancer cells (9, 29, 30, 31). There is also concern that milk thistle might affect estrogen levels. Dosage and side effects. Milk thistle has been an important natural remedy for centuries of folk medicine practitioners. Brittany Lubeck, RD, is a nutrition writer and registered dietitian with a master's degree in clinical nutrition. It can help prevent elevation of liver enzymes, which can be a side effect of the medication. The study researchers hypothesize that milk thistle's antioxidant qualities make it a good candidate for treating conditions like cancer, hepatitis, NAFLD, diabetes, depression, and heart disease. Do not use this product without medical advice if you are breast-feeding a baby. Version: 2.01. People with diabetes should use caution. Silibinin-treatment up-regulated the function through BDNF/TrkB pathway and attenuated autophagy in the hippocampus. This article looks at the evidence to, Whats the life expectancy of someone with cirrhosis of the liver? The .gov means its official. Not available for orders containing UltraNourish. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. The benefits of milk thistle can be attributed to its anti-inflammatory and antioxidant effects. Luckily, more and more experts are turning to natural remedies to answer that question and circumvent the litany of side effects. Milk thistle. JAMA. Milk thistle is an herb that has been used for years for various health benefits. ", National Center of Complementary and Alternative Medicine (NCCAM): "Milk Thistle," Herbs at a Glance: Milk thistle., Medicinenet.com: "Generic Name: Milk Thistle Oral.". Endo-Lysosomal and Autophagy Pathway and Ubiquitin-Proteasome System in Mood Disorders: A Review Article. (silymarin) extract supplementation on antioxidant status and hs-CRP in patients with type 2 diabetes mellitus: a randomized, triple-blind, placebo-controlled clinical trial. 5 Brain Supporting Supplements Youll Want In Your Medicine, According to the International OCD Foundation, selective serotonin reuptake inhibitor (SSRI), UltraThistle, the highest potency milk thistle formula, Review on the Chemistry and Neuroprotective Effects of Silymarin. Milk thistle for alcoholic and/or hepatitis B or C liver diseases--a systematic Cochrane hepato-biliary group review with meta-analyses of randomized clinical trials. Have direct benefits against prostate, breast, and certain cervical cancer cells. Although rare, milk thistle may trigger a number of common and mild side effects. Pain in . World J Gastroenterol. FREE standard shipping only available in the contiguous United States. Risks. The survey revealed anecdotal evidence of the improved quality of life among those who took milk thistle, despite having no measurable improvements in hepatitis symptoms like liver inflammation. Herbal product use by persons enrolled in the Hepatitis C Antiviral Long-Term Treatment Against Cirrhosis (HALT-C) Trial. Its thought to work by making more of the milk-producing hormone prolactin. Brittany Lubeck, RD, is a nutrition writer and registered dietitian with a master's degree in clinical nutrition. Am J Gastroenterol. 1. Milk thistle (silymarin) is a flowering herb related to the daisy and ragweed family. Depression, Milk Thistle, Mood, Silibum Marianum (milk thistle), Silymarin. But the evidence is limited, and some research methodologies are flawed, so its difficult to confirm these effects. There is a reason why milk thistle is called the "liver herb." The flavonoid combo of silymarin (and especially the phytonutrient silybin) can help rebuild liver cells while it removes toxins from that organ at the same time.